Correct Answer d) Quinidine
Quinidine is a Class I antiarrhythmic agent. In general, Class I and pure Class III anti arrhythmic agents have a risk of producing torsades des pointes, a life threatening polymorphic ventricular tachycardia with QT interval prolongation.
Quinidine has recently been used in the medical management of arrhythmias in Brugada syndrome, though the ideal treatment of arrhythmias in Brugada syndrome is implantation of cardioverter defibrillator (ICD).
Temporary pacing and isoprenaline infusion reduces the chance of recurrence of torsades by reducing the QT interval. Intravenous magnesium is very useful in the treatment of torsades des pointes.
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