- Secreted into plasma by kidney
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is secreted into plasma by liver and not the kidney. Binding of PCSK9 to LDL receptors on hepatocytes enhances degradation of the LDL receptors by endosomes. This in turn leads to reduced LDL clearance. Inhibition of PCSK9 with monoclonal antibodies reduce atherosclerosis and cardiovascular events. Read more on PCSK9 inhibitors…
- Bayes-Genis A et al. The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure. BIOSTAT-CHF Subanalysis. J Am Coll Cardiol. 2017; 70:2128-36.
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