Late loss of lumen after PCI
Abstract: Minimal luminal diameter (MLD) at the end of the procedure minus the minimal luminal diameter at the repeat angiogram, generally at 6 months is taken as the late loss of lumen after PCI.
The gain in lumen immediately after a percutaneous intervention (PCI) is known as the acute gain. Acute gain is defined as the difference between the minimal luminal diameter (MLD) before the procedure and after the procedure. Angiograms in multiple projections are needed to measure the minimal luminal diameter because all coronary stenoses are not perfectly circular or symmetric. Most stenoses are in fact eccentric rather than concentric.
Part of the gain may be lost in the long run due to neo-endothelial proliferation and this is known as the late lumen loss after PCI. Late lumen loss at follow up angiogram is an important parameter assessed in clinical trials assessing the use of coronary stents and bioresorbable vascular scaffolds.1
- Zhang YJ, Bourantas CV, Muramatsu T, Iqbal J, Farooq V, Diletti R, Campos CA, Onuma Y, Garcia-Garcia HM, Serruys PW. Comparison of acute gain and late lumen loss after PCI with bioresorbable vascular scaffolds versus everolimus-eluting stents: an exploratory observational study prior to a randomised trial. EuroIntervention. 2014 Oct;10(6):672-80.