Prediction of superresponders to CRT

Prediction of superresponders to CRT

Various types of responses are possible after implantation of a cardiac resynchronization device (CRT) in a person with heart failure. There could be no response (non-responder), good response (responder), and a super response (superresponder). Some could even have a negative response. Superresponders have a good clinical outcome. Those with wide QRS complex indicating extensive intraventricular conduction disease are likely to have a superresponse. They typically have a QRS duration of 150 milliseconds or more and left bundle branch block. Females and those with no previous infarction are likely to have a better response. Body mass index less than 30 kilograms per square meter and small baseline left atrial volume index may also predict a better response [Steffel J et al. Superresponse to Cardiac Resynchronization Therapy. Circulation. 2014; 130: 87-90].